Specific Aim 3

Specific Aim 3 

Examine interactions between T1D and T2D in Asian populations to uncover shared or distinct disease mechanisms.

Lead Postdoctoral Researcher: Yue Wu, PhD

Goals:

  • Uncover Asian-specific meal response and metabolic traits
    • Asian specific metabolic physiologies compared with Europeans. Collected small cohort showed some similarity and differences in the Asian group compared with Europeans.
    • New cohort to evaluate postprandial response and mitigations (controlled meals). In process of securing fundings.
    • Associate the results in 1.1 and 1.2 with enzyme levels though genetics and biobank.
    • Omics analysis of existing Asian participant samples.

Genetics of T1D, T2D, Monogenic Diabetes Among Asians in the Bay Area

Principal Investigators and Co-Principal Investigators: Anna Gloyn, DPhil; Everett Meyer, MD; David Maahs, MD, PhD, MA

Objectives:

  • Establish the genetic etiology of new-onset diabetes in Asian patients in the Bay Area?
  • What proportion of new onset diabetes in Asians in the Bay Area is T1, T2 and monogenic diabetes?
  • Are genetic risk scores for diabetes effective in discriminating between T1 and T2 in the Bay Area Asian population?
  • Are we missing cases of monogenic diabetes in Asian people with diabetes?

Evaluation and Care of Double Diabetes in Asian Americans

Co-Principal Investigators: Rayhan Lal, MD; Marina Basina, MD

Objectives: 

  • To assess markers of insulin resistance (BMI, liver tests, lipids, total daily dose) in people with type 1 diabetes identifying as Asian versus those not identifying as Asian.
  • To compare and characterize metabolic differences between obese/overweight and normal BMI individuals with type 1 diabetes identifying as Asian versus those not identifying as Asian.
  • To assess GLP-1 prescriptions among people with type 1 diabetes identifying as Asian versus those not identifying as Asian.

Impact of NOURISH ADA/AHA Compliant Meals on Postprandial Glycemic Response Using Continuous Glucose Monitoring: A Crossover Quantitative and Qualitative Study

Principal Investigator: Minal Moharir, MD

Objectives:

  • To evaluate the effect of ADA and AHA-compliant meals compared to self-selected diet (SSD) on postprandial glycemic responses of 15 Asian Indian and 15 Filipino adults with T2DM.
  • To assess meal adherence and participant satisfaction with structured meal interventions to inform future implementation for Asian populations.